International Staging for Multiple Myeloma - International Staging

International Staging System

The International Staging System (ISS) is a new, more cost-effective alternative to the Durie-Salmon staging system. The ISS is based on the assessment of two blood test results: beta 2-microglobulin (ß2-M) and albumin. Analyzing beta-2 microglobulin in combination with albumin has shown the greatest prognostic power for multiple myeloma. While the ISS has only recently been developed, it has already been proven more sensitive in discriminating between three stages of myeloma. These stages indicate different levels of projected survival rates and point to increasingly more aggressive myeloma treatment strategies.

International Staging System (ISS) criteria


Stage I

ß2-M < 3.5 mg/dL and albumin =3.5 g/dL

Stage II*

Neither stage I nor stage III
Neither stage I nor stage III

Stage III

ß2-M ≥ 5.5 mg/L