Reduced Kidney Function

Reduced kidney function is another common symptom of multiple myeloma that results in a several different symptoms which include increased or decreased urination, increased thirst, nausea, vomiting, confusion or restlessness.

The excess M proteins secreted by myeloma cells reduce the kidney’s ability to filter the blood. Additionally, the breakdown of bone can cause increased calcium levels in the blood, all of which put extra strain on kidney function. The decreased kidney function may then cause fluctuations in the amount of urine produced. Renal impairment in multiple myeloma patients can be acute or chronic, and more than half of myeloma patients will experience a decrease in their kidney function at some point in the course of the disease. Certain blood tests, such blood chemistry tests, may be used to analyze kidney function. Reduced kidney function in multiple myeloma may also lead to additional complications including kidney failure, hypertension or diabetes.

Learn which tests are used to analyze and diagnose multiple myeloma’s symptoms in the multiple myeloma knowledge center.