Allogeneic Stem Cell Transplants
Allogeneic transplants involve transferring stem cells from a matched donor (usually a relative) to a myeloma patient following high-dose chemotherapy or radiation. This type of transplant is infrequently performed today because of the high risk of complications, although it does offer beneficial effects against the myeloma by boosting the immune system. A mini (non-myeloablative) allogeneic transplant is a modified form of allogeneic transplant that uses somewhat lower doses of chemotherapy to make the transplant safer.
Allogeneic stem cell transplantation is used to cure multiple myeloma patients who are at high risk of relapse, don’t respond fully to treatment, or relapse after prior successful treatments.