MULTIPLE MYELOMA KNOWLEDGE CENTER

What are Pomalyst side effects?

Pomalyst® (pomalidomide, Celgene) side effects primarily depend on individual’s past health history and stage of their myeloma. Pomalyst and low-dose dexamethasone is generally well-tolerated. The most common side effects seen in the Phase II study upon which approval was granted were:

  • Fatigue and weakness
  • Low white blood cell counts (neutropenia)
  • Low red blood cell counts (anemia)
  • Gastrointestinal effects (constipation, nausea, or diarrhea)
  • Shortness of breath
  • Upper respiratory infection
  • Back pain
  • Fever

The most common serious side effects seen in the Phase II study were:

  • Low white blood cell counts
  • Pneumonia
  • Low red blood cell counts
  • Low platelets (thrombocytopenia)
  • Fatigue and weakness

A similar side effect profile was seen in a Phase III study that evaluated Pomalyst and low-dose dexamethasone.

If you experience low white blood cell or platelet counts or other serious side effects while receiving Pomalyst, your doctor may adjust your dose.

Some patients who received Pomalyst in clinical trials developed blood clots. For this reason, you will also receive aspirin or another blood thinner along with Pomalyst.

Women who are pregnant or who plan to become pregnant must not take Pomalyst. This precaution is due to its similarity to thalidomide, and some signs of birth defects in animals. A program has been created (Pomalyst REMS™) to prevent exposure to Pomalyst during pregnancy.

  • Doctors and pharmacists must register with the program in order to prescribe and dispense Pomalyst.
  • Patients must register and meet all the conditions of the program in order to take Pomalyst.