Kyprolis Side Effects - Carfilzomib Side Effects - Myeloma

MULTIPLE MYELOMA KNOWLEDGE CENTER

What are Kyprolis side effects?

Possible Kyprolis® (carfilzomib, Onyx) side effects depend on an individual’s past health history and on their current stage of multiple myeloma.

Single-agent Kyprolis

The most common side effects seen in clinical trials of single-agent Kyprolis were:

  • Fatigue
  • Low red blood cell count (anemia)
  • Nausea
  • Low platelet count (thrombocytopenia)
  • Shortness of breath
  • Diarrhea
  • Fever

The most common serious side effects seen with single-agent Kyprolis in clinical trials were:

  • Low red blood cell count
  • Low platelet count
  • Low white blood cell count
  • Pneumonia

Kyprolis in combination with Revlimid and dexamethasone

The most common side effects seen in the study that led to the approval of Kyprolis in combination with Revlimid® (lenalidomide, Celgene) and low-dose dex were:

  • Low red cell count
  • Low platelet counts
  • Shortness of breath
  • Diarrhea
  • Fatigue

The most common serious side effects seen with Kyprolis-low-dose dex were:

  • Low platelet counts
  • Low red cell count
  • Diarrhea
  • Fatigue

Additional safety information

Kyprolis can cause other serious side effects, including:

  • Heart complications
  • High blood pressure in the lungs (pulmonary hypertension)
  • Shortness of breath
  • Infusion reactions
  • Tumor lysis syndrome
  • Liver or kidney toxicity
  • Visual or neurological symptoms
  • Harm to a developing fetus

Patients may experience infusion reactions immediately following or up to 24 hours after receiving Kyprolis. These reactions can include fever, chills, achiness, flushing, facial swelling, vomiting, weakness, shortness of breath, low blood pressure, fainting, chest tightness and chest pain. However, dexamethasone given prior to Kyprolis reduces the incidence and severity of these reactions.

Importantly, there was a low incidence of peripheral neuropathy in clinical studies and it was generally mild when it occurred.

Patients experiencing severe side effects may have their Kyprolis dose reduced or may have Kyprolis temporarily stopped until the side effects resolve.

Please tell your doctor or nurse if you experience any side effects.