Side Effects - Multiple Myeloma Research Foundation

MULTIPLE MYELOMA KNOWLEDGE CENTER

What are Farydak side effects?

Farydak® (panobinostat, Novartis) side effects vary from patient to patient and may be influenced by the current stage of a patient’s myeloma.

The most common possible side effects of Farydak include:

  • Diarrhea
  • Fatigue
  • Nausea
  • Swelling in the arms or legs (peripheral edema)
  • Decreased appetite
  • Fever
  • Vomiting

Serious side effects that have been reported with Farydak include:

  • Severe diarrhea
  • Heart toxicity, including reduced blood flow to the heart, severe heart rhythm disturbances, and electrocardiogram changes
  • Bleeding in the lungs or gastrointestinal tract
  • Severely low platelet, white blood cell, or red blood cell counts
  • Infection
  • Liver problems (hepatotoxicity)
  • Fetal harm

How are side effects of Farydak managed?

Patients receiving Farydak will be monitored carefully for side effects and have periodic blood tests performed. Side effects of Farydak can often be managed with other medications, by increasing the amount of fluids, reducing the dose of Farydak, or stopping Farydak treatment temporarily until symptoms resolve.

Because of the risk of harm to an unborn baby, women should take steps to avoid becoming pregnant while taking Farydak. Women should use effective birth control during treatment with Farydak and for 1 month after stopping treatment. Men should use a condom during treatment with Farydak and for 3 months after stopping treatment.