Side Effects - Multiple Myeloma Research Foundation


What are Evomela side effects?

In clinical studies in patients with myeloma, the most common side effects seen with Evomela™ (melphalan, Spectrum Pharmaceuticals) included:

  • Low numbers of white blood cells in general, including neutrophils (neutropenia) and lymphocytes
  • Low platelet counts, also referred to as thrombocytopenia
  • Gastrointestinal effects (diarrhea, nausea, or vomiting)
  • Fatigue
  • Low potassium levels
  • Anemia, or low numbers of red blood cells

Rarely, allergic reactions, including anaphylaxis, have been reported with conventional intravenous melphalan.

The most common serious side effects seen with Evomela included fever, blood in the stool, neutropenia with fever, and kidney failure.

How are side effects of Evomela managed?

Patients experiencing side effects with Evomela may have their dose reduced or delayed until symptoms resolve. Patients who experience severe allergic reactions will have their treatment stopped.