In August 2007, the Multiple Myeloma Research Foundation (MMRF) and The Multiple Myeloma Research Consortium (MMRC) launched the world's only myeloma-specific repository of genomic data. The MMRC Multiple Myeloma Genomics Portal (http://www.broad.mit.edu/mmgp) provides the scientific community with open access to high-resolution genomic data from the MMRC Multiple Myeloma Genomics Initiative prior to publication and in near real-time.
The MMRC Multiple Myeloma Genomics Portal is a critical component of the MMRC Multiple Myeloma Genomics Initiative, a cutting-edge genome-mapping program spearheaded and funded by the MMRF and MMRC and conducted with the support of and in collaboration with the Broad Institute of MIT and Harvard and the Translational Genomics Research Institute (TGen). Comprised of several research and discovery efforts spanning the spectrum of genomic science, the MMRC Multiple Myeloma Genomics Initiative is the most comprehensive research effort of its kind.
The MMRC Multiple Myeloma Genomics Portal's launch includes the first disclosure of an MMRC dataset containing the highest-resolution DNA copy number analysis of patient's multiple myeloma tumor tissue published to date with matching gene expression profiles on 94 samples, as well as data from other myeloma genomic efforts.
In the coming months, preliminary data from RNA interference (RNAi) screens will be placed in the MMRC Multiple Myeloma Genomics Portal; when fully analyzed, the RNAi screening results will help guide the selection of novel targeted therapeutics for treating multiple myeloma. In addition, sophisticated bioinformatics tools will be added to the MMRC Multiple Myeloma Genomics Portal within the next year, and the inclusion of data from genomic studies in other cancers is planned. By mid-2009, the MMRC Multiple Myeloma Genomics Initiative will have screened a total of 250 patient samples using a broad range of state-of-the-art genomic approaches; data from these screens will be immediately placed in the MMRC Multiple Myeloma Genomics Portal.
At the core of this unique model is the MMRC Tissue Bank, the only resource of its kind that integrates myeloma tissue samples with corresponding genomic and clinical data to enable researchers to rapidly advance research efforts.