| Dose Modification for Pomalyst for Hematologic Toxicity |
| Side Effect |
Modification of Dose and Regimen |
| Neutropenia
|
| ANC* < 500 per mcL or febrile neutropenia (fever of 38.5°C or higher and ANC < 1,000 per mcL) |
Interrupt Pomalyst treatment, follow complete blood count weekly |
| ANC return to more than or equal to 500 per mcL |
Resume Pomalyst at 3 mg daily |
| For each subsequent drop < 500 per mcL |
Interrupt Pomalyst treatment |
| Return to more than or equal to 500 per mcL |
Resume Pomalyst at 1 mg less than the previous dose |
|
| Thrombocytopenia |
| Platelets < 25,000 per mcL |
Interrupt Pomalyst treatment, follow complete blood count weekly |
| Platelets return to > 50,000 per mcL |
Resume Pomalyst treatment at 3 mg daily |
| For each subsequent drop < 25,000 per mcL |
Interrupt Pomalyst treatment |
| Return to more than or equal to 50,000 per mcL |
Resume Pomalyst at 1 mg less than previous dose. |
|
|
*ANC stands for Absolute Neutrophil Count; mcL stands for microliter.
For other serious side effects, Pomalyst is stopped until the toxicity has resolved or been reduced. At that point, Pomalyst is restarted at 1 mg less than the previous dose.
Before a new cycle of Pomalyst is started, the neutrophil count must be at least 500 per mcL and the platelet count must be at least 50,000 per mcL.
